Furthermore, morpholino silencing of the gene that encodes the β1 (adrb1) but not β2 (adrb2) receptor also prevents CVP cavernomas (Li et al., 2021a), suggesting that the β1 adrenergic receptor (β1AR), which primarily impacts hemodynamics (van den Meiracker et al., 1989), contributes to the pathogenesis of CCM. The gene discussed is ADRB1; the disease is cavernous hemangioma.