More interestingly, ChIP-qPCR results showed that NCAPH-KD significantly reduced the binding efficiency of E2F1 to the proximal promoters of CDK1 and CCNB1, thereby reducing the transcription of CDK1 and CCNB1 genes in these PCa cells (Figures 5F and G). Here, E2F1 is linked to posterior cortical atrophy.