CXCL1 and Alzheimer disease: These results suggest that this nomogram model, using machine learning identified four immune-related genes <i>CXCL1</i>, <i>ITGA5</i>, <i>PTX3</i>, and <i>TIMP1</i>, displays superior diagnostic ability in distinguishing AD and healthy individuals, and immune cells commonly associated with these hub genes may be therapeutic targets for AD.