Therefore, the aim of this study was to assess the relationship between cardiometabolic parameters and circulating levels of visfatin, adropin, and adiponectin in perimenopausal women with regard to their obesity status.<h4>Materials and methods</h4>This study of 168 perimenopausal women utilized a cross-sectional design with non-random sampling. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.