IL10 and Sepsis: In a sepsis model induced by cecal ligation and puncture (CLP), the administration of exogenous IL-33 enhances bacterial clearance, leading to improved survival of septic mice; at 24 h after CLP, IL-33 attenuates the system inflammation, represented by the decreased levels of IL-6, IL-10, TNF-α, and IFN-γ in serum, as well as the severity of organ injury, which was likely due to IL-33 prevented apoptosis of T lymphocytes and improved bacterial clearance [45].