The depletion of YEATS2 or disruption of its interaction with acetylated histones reduces promoter H3K9ac levels and deactivates the expression of essential genes, underlying its pivotal role in lung cancer tumorigenesis (YEATS2 links histone acetylation to tumorigenesis of NSCLC).Furthermore, the role of YEATS2 in various tumors, overexpression of YEATS2 promotes the proliferation and migration of pancreatic cancer cells, and it has been associated with the progression of lung cancer through histone acetylation. Here, YEATS2 is linked to non-small cell lung carcinoma.