CTLA4 and cancer: The results showed that MATN3 expression was positively correlated with cytotoxic T lymphocyte antigen 4 (CTLA4), CD274 (PD-L1), programmed cell death 1 (PDCD1 or PD1), and lymphocyte activation gene 3 (LAG3) in the majority of cancer types, but the opposite was true for THYM, which was negatively correlated with most of the immune checkpoint genes (Figure 4A).