MAP2K6 and esophageal adenocarcinoma: Studies have shown that the elevated expression level of MAP2K6 could significantly accelerate the cell survival and colony formation ability of nasopharyngeal carcinoma cells 25, and suggested that nasopharyngeal cancer patients had a poor prognosis 26; shRNA-mediated knockdown of MAP2K6 hindered the proliferation of esophageal adenocarcinoma cells and restrains tumor growth 27; The expression level of MAP2K6 was significantly elevated in patients with polycystic ovary syndrome (PCOS) 28.