Univariate Cox regression analysis showed that T classification (p < 0.001, HR = 1.633, 95% CI: 1.345-1.983), M classification (p = 0.046, HR = 1.516, 95% CI: 1.008-2.279), tumor stage (p < 0.001, HR = 1.652, 95% CI: 1.348-2.026) and MCM3 expression (p = 0.007, HR = 1.668, 95% CI: 1.151-2.418) were significantly associated with the prognosis of HCC patients. The gene discussed is MCM3; the disease is hepatocellular carcinoma.