Interestingly, NUPR1 forms a protein complex with a histone citrullination enzyme, peptidyl arginine deiminase 4 (PADI4/PAD4), in cancer cells 44, and PADI4 interacts with the C-terminus of TP53 and functions as a TP53 co-repressor 45, 46. The gene discussed is NUPR1; the disease is cancer.