Collectively, these results suggest that the upregulation of NUPR1 partially promotes the survival of MCF7-TamC3 breast cancer cells by switching the survival reliance from the estrogen-ER-signaling to the EGF-ERBB2-signaling, modulating the TP53-signaling pathway, and upregulating the expression of BIRC5. This evidence concerns the gene NUPR1 and breast cancer.