This showed that RIG-I-mediated IFNα secretion is blocked by ALKBH5 overexpression through the IKKε/TBK1/IRF3 pathway, suggesting a new mechanism governing IFNα production in the tumor microenvironment 104 Since histone demethylase affects OSCC development modulation, these above enzymes might be considered as crucial prognostic markers and therapeutic targets for OSCC progression. The gene discussed is ALKBH5; the disease is neoplasm.