EZH2 and neoplasm: For instance, in the case of cancer, a high level of H3K27me3 was related to tumour progression (advanced T and N status, and stage of tumour) by preventing gene expression through the action of an enzyme called enhancer of zeste homolog 2 (EZH2/KMT6), which trimethylates histone H3 lysine 27 and subsequently causes transcriptional repression of target genes 39, 69, 70.