A curated selection of ligand-receptor pairs was portrayed in Figures 6c-d, revealing a subset shared between BLCA and control environments—specifically, interaction pairs such as APP-TNFRSF21, APP-CD74, IGFBP3-TMEM219, CXCL14-CXCR4, TYROBP-CD44, and CD99-PILRA stood out, illustrating the conservation of certain cellular communication pathways despite the diseased state. This evidence concerns the gene TNFRSF21 and bladder transitional cell carcinoma.