Åkesson J et al.47 identified 11 CSF proteins (CXCL13, LTA, FCN2, ICAM3, LY9, SLAMF7, TYMP, CHI3L1, FYB1, TNFRSF1B, and NfL), including ICAM3, through proteomics to predict the severity of disability worsening based on normalized age-related multiple sclerosis severity scores (replication AUC = 0.90) (Figure 5). The gene discussed is FCN2; the disease is multiple sclerosis.