Compared with these results, our data showed consistency with the rs33917957 expressed in gastric cancer that the cigarette smokers of male oral cancer patients who carried the MET rs33917957 “AG + GG” polymorphic variants were associated with lower risk to develop moderate or poorer cell differentiated grade, and the ligand binding affinity from MET N375 to S375 may play an essential role in oral cancer. Here, MET is linked to lip and oral cavity carcinoma.