The subsequent multivariate analysis revealed that the number of metastatic tumors (HR 2.48, P < 0.001), cN stage (HR 3.32, P < 0.001), KRAS (HR 1.74, P < 0.05), BRAF (HR 2.81, P < 0.001), age (HR, P < 0.05), original site (HR 1.83, P < 0.05), neutrophil count (HR 1.61, P < 0.05), platelet count (HR 2.58, P < 0.05), D-Dimer (HR 1.62, P < 0.05) were identified as independent predictors. This evidence concerns the gene KRAS and metastatic neoplasm.