Busiman et al.15 integrated several factors including age, gender, location and nodal status of CRC, disease-free interval, number and size of CRLM, preoperative CEA levels, resection margin, presence of extrahepatic disease, KRAS and BRAF mutation status, histopathological growth pattern, perioperative systemic chemotherapy, and perioperative hepatic arterial infusion pump (HAIP) chemotherapy into their clinical prediction model using Cox regression analysis, yielding satisfactory predictive performance. This evidence concerns the gene CEACAM5 and colorectal carcinoma.