The optimal cutoff values to diagnose T2DM in the geriatric population determined using the Youden index were as follows: CRP (>3.80 μg/ml), TNF-α (>22.90 pg/ml), IL-6 (>4.67 pg/ml), cortisol (>103.15 ng/ml), adiponectin (≤7.42 μg/ml), and IL-10 (≤5.19 pg/ml). This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.