<h4>Objective</h4>To develop a nomogram based on multi-sequence MRI (msMRI) radiomics features and imaging characteristics for predicting human epidermal growth factor receptor 2 (HER2) expression in breast cancer (BC).<h4>Methods</h4>206 women diagnosed with invasive BC were retrospectively enrolled and randomly divided into a training set (n = 144) and a validation set (n = 62) at the ratio of 7 : 3. Here, ERBB2 is linked to breast cancer.