With the combination of edema and enhancement types, the nomogram achieved the highest performance in the training set (AUC: 0.940) and validation set (AUC: 0.893).<h4>Conclusion</h4>The developed multi-sequence MRI-based nomogram presents a promising tool for predicting HER2 expression, and is expected to improve the diagnosis and treatment of BC. Here, ERBB2 is linked to breast cancer.