Model performance was evaluated using internal validation with the Bootstrap method, assessing discrimination, calibration, and clinical validity.<h4>Results</h4>Factors such as history of diabetes, fasting plasma glucose (FBG), triglyceride (TG), homocysteine (Hcy), and C-reactive protein (CRP) were identified as single factors for early functional deterioration in IS patients (P<0.05). Here, CRP is linked to diabetes mellitus.