With regard to Treg, SCFA increases histone acetylation by inhibiting HDAC, which can differentiate primitive T cells into Treg and increase Foxp3 expression via Gpr43, thereby increasing Fox P3+ T-cell activity and IL-10 production (140), producing an anti-inflammatory effect and thus alleviating the progression of hypertension (139). Here, FOXP3 is linked to Hypertension.