In detail, this increased fecal SCFA observed in NASH was associated with a decreased number of resting Treg cells (CD4+CD45RA+CD25+) and a higher ratio of Th17 cells to resting Treg cells in the peripheral blood, which is a systemic immune feature observed in NASH (180). The gene discussed is CD4; the disease is metabolic dysfunction-associated steatohepatitis.