CCN2 and polycystic ovary syndrome: It is worth mentioning that recent studies on SCFA for polycystic ovary syndrome (PCOS) in relation to inflammation in the heart have become progressively more frequent, and it has been found that acetate can reverse cardiac energy depletion, alleviate nitric oxide (NO/eNOS) deficiency, elevate SIRT-1/HIF-1α levels, and decrease CTGF/TGFβ-1 in an experimental PCOS model by inhibiting HDAC2, oxidative stress (malondialdehyde)/inflammation (NF-κB/SDF-1) markers, and plasma troponin T levels (195).