Levels of neutrophil granule proteins, including myeloperoxidase (MPO) and neutrophil elastase (NE), and pyroptosis factors were examined.<h4>Results</h4>Levels of neutrophil granule proteins (MPO, 82.9 vs. 175.3, <i>p</i> < 0 <.0001; NE, 56.3 vs. 144.2, <i>p</i> < 0.0001) were significantly higher in patients with sepsis with lymphopenia. Here, MPO is linked to lymphopenia.