Western blot analysis confirmed the upregulation of ALOX15 in FD podocytes, with validation of other markers implicating ferroptosis in FD pathology.<h4>Conclusion</h4>These findings underscore the heterogeneity of FD and, for the first time, implicate ferroptosis as a potential common pathway driving its pathology. The gene discussed is ALOX15; the disease is Fabry disease.