<h4>Background</h4>In this study, we investigated whether serum glutathione peroxidase-1 (GPX-3) concentration at diagnosis could be used to assess vasculitis activity and damage at diagnosis in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).<h4>Methods</h4>We included 71 immunosuppressive drug-naïve patients newly diagnosed with AAV. This evidence concerns the gene GPX1 and anti-neutrophil cytoplasmic antibody-associated vasculitis.