Six prognostic LRGs, including two protective genes (<i>FTCD</i> and <i>APCS</i>) and four risk genes (<i>LGALS3</i>, <i>C1orf43</i>, <i>TALDO1</i>, and <i>CCT5</i>), were identified to develop a Riskscore model with a strong prognostic prediction performance in HCC. This evidence concerns the gene LGALS3 and hepatocellular carcinoma.