According to previous reports, MSI2 can interact with mRNAs and regulate the translation of several oncogenic proteins related to cancer signaling pathways, such as the TGFβ/SMAD, mTOR, PI3K/Akt, cMET, NUMB/Notch, cMyc, and Hh signaling pathways 47. Here, TGFB1 is linked to cancer.