Keane et al. reported that the synthesis of monounsaturated fatty acids by stearoyl CoA desaturase SCD stabilized β-catenin and ELAVL1 expression, and ELAVL1 further stabilized the levels of LRP5 and LRP6, two important proteins in the β-catenin signaling pathway, promoting liver fibrosis and liver cancer 42. The gene discussed is LRP6; the disease is liver cancer.