The results showed that in BAP31 knockdown HCC cells, the expression of SPINK6 was significantly decreased, and the expression of MRP2 and E-cadherin was increased; in contrast, the expression levels of NTCP (basal membrane marker), N-cadherin and Vimentin were significantly decreased (Figure 2F, G). The gene discussed is CDH2; the disease is hepatocellular carcinoma.