Intriguingly, the results of the pilot study showed that (1) XO activity remarkably elevated and significantly positive correlated to heart and kidney dysfunction in rat CRS model by day 42 after CRS induction and (2) the kidney injury score and fibrosis, XO activity and generation of ROS in LV myocardium and kidney parenchyma were substantially augmented in CRS animals as compared with the SC groups. The gene discussed is XDH; the disease is congenital rubella syndrome.