An essential finding in the present study was that at the end of study period, the circulating levels of FGF23 (i.e., an inhibitor of renal phosphate reabsorption), BNP (a heart failure marker) and XO (an oxidative stress expressed in circulation) were significantly increased CRS animals than in SC animals, implicating that CRS could also be reliably evaluated for the severity of its clinical presentation by these circulatory biomarkers. Here, XDH is linked to heart failure.