In the pilot studies, our missions were to elucidate several issues at day 42 after CRS induction, including the circulatory level of XO activity in CRS animals, the correlations between circulatory XO activity and circulatory creatinine, BUN and BNP levels, LVEF and the ratio of urine protein to urine creatinine as well as the XO activity in LV myocardium and kidney in CRS animals. Here, NPPB is linked to congenital rubella syndrome.