CCND1 and neoplasm: In addition, protein expression of PCNA, CyclinD1, Bcl-2, Integrin α2/β1, p-FAK, p-PI3K (p85), p-AKT, p-mTOR, C-myc proteins were also significantly increased in the DLD-1 xenograft tumor treated with S. moorei and were reversed by RGD peptides in S. moorei-treated DLD-1 xenograft tumor (Figure 6E).