siRNA-mediated silencing of integrin α2/β1 in CRC cells also showed similar effects following incubation with S. moorei, integrin α2, integrin β1, p-FAK, p-PI3K, p-AKT, p-mTOR, C-myc, and PCNA protein levels were also downregulated in CRC cells exposed to S. moorei following transfection with siRNA targeting integrin α2/β1 (Figure 5E-F and S3F-G). This evidence concerns the gene PCNA and colorectal carcinoma.