PIK3R1 and colonic neoplasm: Expression levels of Pcna, Ccnd1(CyclinD1), Bcl2, Itga2, Itgb1, Fak, Pik3r1, Akt1, Mtor and Myc were remarkably upregulated and Bax was downregulated in colonic tumors of mice treated with S. moorei (Figure S4A).