We found that key genes related to the PI3K-AKT pathway were significantly increased in CRC cell lines co-cultured with S. moorei, including ITGA2, ITGB1, PTK2(FAK), PIK3R1, AKT1, MTOR and MYC (Figure 5B and S3A). The gene discussed is ITGA2; the disease is colorectal carcinoma.