TGFB1 and diabetic kidney disease: Using a murine model of graded expression of Tgfb1 (10% hypomorph to 300% hypermorph) in type 1 diabetic Akita mice, the authors demonstrated that the global suppression of TGF-β1 levels prevents DKD development, while increased expression markedly exacerbates it akin to advanced human DKD 39.