Selective inhibitors of p38 or JNK (NPC31145, NPC31169, FR167653, and SB203580 for p38; SP600125, CC401 and CC930 for JNK) have been shown to reduce podocytes injury, inflammation and fibrosis in animal models of anti-glomerular basement membrane (GBM) glomerulonephritis, ureteral obstruction, and diabetic nephropathy 180-187. Here, MAPK8 is linked to Ureteral obstruction.