XDH and hyperuricemia: Quercetin, a naturally occurring flavonoid, has shown potential as a hypouricemic agent through XO inhibition.<h4>Objective</h4>This study aims to evaluate the potential hypouricemic effect of Quercetin PhytosomeTM (QP) supplementation across three cohort studies involving healthy adults with various metabolic health profiles, exploring its potential as a safe, effective intervention for hyperuricemia.<h4>Methods</h4>Clinical data collected in various clinics in Italy between September 2021 and April 2024 under real-life clinical settings from three distinct cohort studies, were analyzed.