SST and Alzheimer disease: One key finding from our previous work is that SEA-AD and the two largest studies of dorsolateral prefrontal cortex (DFC) (Mathys et al., 2023; Green et al., 2023) show common abundance changes in AD, including loss of supragranular somatostatin (SST) neurons and gain of disease-associated microglia (Gabitto et al., 2024).