Previous studies have explored the use of ISRIB, and ISR inhibitor, to restore cognitive deficits in mice.46 Furthermore, our screen revealed that knockdown of EIF2AK3, EIF2AK4, and ATF4 reduced excitability, in line with previous work showing the role of eIF2a in long-term memory formation.47,48 These hit genes highlight that neuronal excitability is influenced by diverse molecular pathways and that the CaMPARI2-based screening method is capable of detecting neuronal excitability modifiers that are upstream in these pathways. Here, EIF2A is linked to Cognitive impairment.