Indeed, IGHG variants have been associated with disease outcomes in multiple contexts, including but not limited to multiple sclerosis (MS)27, human cytomegalovirus (HCMV) infection28, Myasthenia Gravis29, Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD)30, and COVID severity31. The gene discussed is MOG; the disease is myeloid sarcoma.