When comparing the female rats to the male rats, the female rats were found to have: a lower proportions of Kcnip1+ adipocytes at 24 weeks on both HF and control diets, a higher proportion of Bmper+ fibroblasts at 24 weeks on control diet, a higher proportion of Piezo2+ lymphatic ECs at 24 weeks on HF diet, a lower proportions of neutrophils at 8 weeks in both HF and control diets, a lower proportion of B cells at 24 weeks in the HF diet, and a lower proportion of monocytes at 8 weeks on the HF diet. The gene discussed is PIEZO2; the disease is hydrops fetalis.