This study investigated frequencies of <i>GC</i> genotypes and phenotypes in Kuwaiti multiple sclerosis (MS) patients and healthy controls, and their associations with serum levels of 25 hydroxyvitamin D [25(OH)vitamin D] and VDBP.<h4>Methods</h4>The genomic DNA was isolated from blood samples of drug-naïve MS patients (<i>N</i> = 151) and controls (<i>N</i> = 127). Here, GC is linked to multiple sclerosis.