Methods: To investigate the role of CD34+ SPCs in transplant arteriosclerosis, we used various genetically modified mouse models, including BALB/c, C57BL/6J, CD34-CreERT2, Rosa26-tdTomato, Rosa26-iDTR, CD34-Dre, PI16-CreERT2, and CAG-LSL-RSR-tdTomato-2A-DTR mice. This evidence concerns the gene CD34 and arteriosclerosis disorder.