Prior data, concentrating on PC, also found that elevated Ki-67 expression correlated with adverse pathological characteristics, such as poor tumor differentiation, high tumor grade, and the development of lymph node metastases 115, 116, and was an independent predictor of unfavorable disease-free survival and disease-specific survival outcomes in PC and had a strong correlation with tumor grade 116-118. Here, MKI67 is linked to pachyonychia congenita.