Consistent with no difference in NF-α1/CPE levels with fl/fl:AD mice, the fl/fl: Camk2a-Cre-AD mice at 9 mths showed no difference in cognitive dysfunction, Aβ deposition and expression, microglia numbers and their total branch length, as well as the number of microglia per Aβ plaque, compared to fl/fl:AD mice (Figure S3D-T). Here, CAMK2A is linked to Alzheimer disease.