In our study, we observed decreased amyloid plaque accumulation, mitigated spatial memory deficits, and normalized hippocampal synaptogenesis and microglial anomalies across early and late stages of the disease, similar to the rescue of neurodegenerative processes seen in the 3xTg-AD and APP/PS1 mouse models after CPE augmentation. Here, PSEN1 is linked to Alzheimer disease.