As suggested from the time course of decline of NF-α1/CPE with age in 5xFAD mice shown in Figure 1B, C, 9 mths old, fl/fl: AD mice and fl/fl: Camk2a-Cre-AD mice probably have reached maximum decline of NF-α1/CPE level. The gene discussed is CAMK2A; the disease is Alzheimer disease.