Results similar to 5 and 7 mth old AD mice in the rescue of learning and memory deficits (Figure S7D-J) and reduction of Iba1+ microglia and GFAP + astroglia cell number (Figure S7K, L, Figure S8) and Aβ plaques and expression (Figure S7M-O) were obtained for the AAV-CPE treated versus untreated AD mice. This evidence concerns the gene AIF1 and Alzheimer disease.