NSUN2 and cardiac hypertrophy: To accurately elucidate the potential role of Nsun2 in the cardiac remodeling course, we developed a modified transverse aortic constriction (MTAC)-induced cardiac hypertrophy mouse model with a reduced aortic constriction degree (MTAC, 25-gauge needle, outer diameter 0.51mm; traditional TAC, 27-gauge needle, outer diameter 0.41mm; Figure S1A-B), which would better recapitulate the remodeling stages 33,34.