CUT&Tag-qPCR results revealed a significant increase in Creb1 levels at the promoters of B7-H1, B7-H2, and B7-H3 in tumor cells following lactate stimulation, with the enrichment of Creb1 at the B7H3 promoter region being the most pronounced, suggesting a potential influence of Creb1 on the expression of B7-H3 (Figure 3H). Here, CD80 is linked to neoplasm.