PANX1 and infection: Other functions of Panx1 HCs include favoring the activation of CD4+ T lymphocytes through a P2X1/4R- and MAPK-dependent mechanism 12, 13, participating in the activation of the endothelium in the event of infection to enhance diapedesis of leukocytes 14, accelerating dendritic cell migration 15, and regulating trafficking of pathogenic patterns from endosomes to the cytosol in response to ATP 16.