CD274 and non-small cell lung carcinoma: Other possible prognostic factors, such as PD-L1 expression, total number of metastases, smoking status, and N stage, were not associated with survival outcomes, emphasizing the need for larger future prospective trials to identify true prognostic factors for patients with sOMD NSCLC.24, 25, 26, 27, 28, 29, 30 Interestingly, the presence of bone metastases was not associated with reduced survival in the subgroup treated with LRT, whereas in the metastatic setting, bone metastases are associated with poor outcomes.31