A treatment algorithm was created for the most common MAEs: xerostomia managed with saliva and lubricants; mucositis with steroid rinses; rashes with topical steroids with or without topical ammonium lactate; periorbital edema with cold or caffeine compresses; and xerosis and pruritus with emollients.<h4>Conclusions</h4>Selective RET inhibition is associated with a unique MAE profile. Here, RET is linked to mucositis.