Moreover, the distinct OPTN immunopositive lewy-body-like hyaline inclusions were also confirmed in the cases of ALS caused by chromosome 9 open reading frame 72 (C9orf72), fused in sarcoma (FUS) and SOD1 mutations (Hortobágyi et al., 2011). This evidence concerns the gene OPTN and amyotrophic lateral sclerosis.