NQO1 and Alzheimer disease: Notably, proteasome activity can be inhibited during oxidative stress and neuroinflammation by CCRs, and mutations of CCRs that regulate cellular defense against oxidative stress, including NQO1, are associated with increased risk of developing AD (Bian et al., 2008; Tsvetkov et al., 2011; Moscovitz et al., 2015).