The identification of the structural features underlying allosteric regulation of degradation by the 20S also provides insight relevant to the development of selective, synthesized inhibitors of 20S proteasomes and possible therapeutic options for neurodegenerative diseases like PD, which is directly affected by a CCR called DJ-1 and is discussed later in this review (Moscovitz et al., 2015). The gene discussed is PARK7; the disease is neurodegenerative disease.