EDN1 and systemic sclerosis: <h4>Background</h4>There is an ongoing search for novel biomarkers of vascular dysfunction, extent of fibrosis and organ involvement in systemic sclerosis (SSc).<h4>Objectives</h4>We critically appraised the studies investigating the circulating concentrations of endothelin-1 in SSc patients and healthy controls.<h4>Design</h4>This was a systematic review with meta-analysis.<h4>Data sources and methods</h4>We searched electronic databases (PubMed, Scopus, and Web of Science) from inception to 15 June 2024.