APP and Alzheimer disease: Therefore, to test the hypothesis that epichaperomes directly contribute to memory dysfunction and validate our dfPPI findings, we assessed synaptic plasticity and memory through the 2-day radial-arm water maze (RAWM), fear conditioning, object location tasks (OLT), and LTP— a type of synaptic plasticity that is thought to underlie memory formation— in APP NL-F and WT mice treated with either an epichaperome disruptor, PU-AD, or with vehicle control (Fig. 9a, 10a).