We analyzed epichaperome formation in key AD-vulnerable brain regions in APP NL-F mice at 3, 7, and 12–14 months of age, focusing on hippocampal subfields (pyramidal layers of CA1 and CA3, the polymorph and granule cell layers of the dentate gyrus, DG), dorsal subiculum, entorhinal cortex, and frontal cortex (Fig. 4a and Supplementary Fig. 5). The gene discussed is APP; the disease is Alzheimer disease.