Untreated APP NL-F mice spent similar time exploring both moved and non-moved objects, indicating impaired spatial memory, while PU-AD-treated mice in both prevention and reversal paradigms showed a significant preference for the moved object, mirroring WT behavior (p=0.0006 for short-term, p=0.0002 for long-term memory in the prevention group; p=0.0024 and p=0.0066, respectively, in the reversal group). The gene discussed is APP; the disease is Alzheimer disease.