We used the T1D Knowledge Portal and found that all 23 and 12 replicated cis-pQTLs for CFB and C4A respectively have been reported genome-wide significantly (p-value<5×10−8) associated with T1D risk (Additional file 3: Table S2; Additional file 1: Fig. S6–7). The gene discussed is CFB; the disease is type 1 diabetes mellitus.