CTBS and cancer: Expression for these 10 CTB-associated miRNAs was also compared between tumour and normal samples within The Cancer Genome Atlas (TCGA) cohorts, and several cohorts showed expression differences between malignant and non-malignant samples for these miRNAs (Supplementary Fig. 3); expression of oncogenic miRNAs is generally upregulated in cancers, where high expression of these oncomirs leads to suppression of key target tumour suppressor genes64.