In the context of skin sensitization, dermal DCs and/or CX3CR1 DCs play a role in allergen delivery to LNs and spleen, and IL-13 has a selective role in providing the activation signal for cDC2s to increase antigen-presenting capacity and promote robust IgE responses via memory Th2 and TFH2 cells. Here, CX3CR1 is linked to skin sensitization.