H2AX and neoplasm: Figure 7A shows that theexpression level of γ-H2AX in RMS559 is higher than that inthe negative control RD cells after treatment with the radioligands.The clonogenic assays presented in Figure 7B,D suggest that the conjugate is significantlymore effective in RMS559 cells than in RD cells. Similar results werealso found using spheroids (Figure S11).These results suggest that eFGF1 can deliver more 161Tbto cells and cause stronger damage to DNA to inhibit the proliferationof FGFR overexpressing tumor cells.